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| 1. How many substrates can this reaction effectively target? | |
| 2. What is the average product yield percentage? | |
| 3. How long does the reaction take to reach completion? | |
| 4. What temperature is required for the reaction? | |
| 5. What is the estimated cost of reagents per gram (or mL) of product? | |
| 6. What percentage of atoms in the reactants end up in the final product? | |
| 7. How many purification steps are required? | |
| 8. How many kilograms of waste are produced per kilogram of product? | |
| 9. What is the energy requirement per kilogram of product? | |
| 10. Can this reaction be scaled without modifications? | |
| 11. What level of equipment is needed to perform this reaction? | |
| 12. What level of catalyst is needed for the reaction? |